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Reagent 2-amidite Catalogue number: 501-07 Purity: >95% A 2,4-dihydroxybutyramide-derived reagent, enantiomerically pure. Suitable for 5’ and internal labeling. Stable to all ONS steps. When on 5’, stable to ammonolysis with DMT-on. Oligonucleotides synthesized undergo smooth conjugation to azides in the presence of copper(I) species. When the label is 5’-terminal, oligonucleotide should be subjected to ammonolysis only in DMT-on mode. Price and Ordering Information Rereferences: 1. Dioubankova, N.N.; Malakhov, A.D.; Stetsenko, D.A.; Gait, M.J.; Korshun, V.A. Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides. Tetrahedron, 2006, 62, 6762–6773. 2. Ustinov, A.V.; Dubnyakova, V.V.; Korshun, V.A. Perylene Diimide- Oligonucleotide Conjugates Constructed by Click Chemistry. Nucleosides Nucleotides & Nucleic Acids, 2007, 26, 751–754. 3. Ustinov, A.V.; Dubnyakova, V.V.; Korshun, V.A. A convenient “click chemistry” approach to perylene diimide–oligonucleotide conjugates. Tetrahedron, 2008, in press. |
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